Job Title: Invitro ADME Bioanalyst (MET-ID Scientist)
Job Location: Bangalore
Date: 15 Jan 2025
Company: Syngene International Ltd. (www.syngeneintl.com)
Experience Required: 6 to 9 years of relevant industrial experience
Education: M. Pharm in Pharmaceutical Sciences or relevant master’s degree in pharmaceutical sciences/instrumentation
Syngene is an innovation-led contract research, development, and manufacturing organization providing integrated scientific services from early discovery to commercial supply. Safety is a core value at Syngene, and employees are expected to uphold the highest standards of environmental, health, and safety (EHS) practices.
Adherence to safe practices and procedures.
Contribution to the development of safety procedures and compliance systems.
Promotion of a corporate culture emphasizing EHS awareness and discipline.
Completion of mandatory training on data integrity, health, and safety measures.
Compliance with Syngene’s quality standards.
Accountability for personal and team safety goals.
Regular review and governance of safety metrics.
The role involves bioanalytical analysis using LC-MS/MS for ADME screening assays, including in vitro assays, MET ID, and large molecule analysis, in alignment with business needs.
Develop high-throughput, fit-for-purpose LC-MS/MS and HPLC-UV methods for ADME sample analysis, including:
Formulation analysis
Solubility studies
Stability studies
MET ID and large molecule analysis
Conduct analysis of ADME assay samples and process different matrices/formulations with minimal supervision.
Operate, maintain, and troubleshoot HPLC/LC-MS/MS systems.
Prepare protocols, reports, and templates related to bioanalytical activities.
Schedule instrument maintenance and ensure regulatory compliance in documentation.
Ensure quality data delivery within set timelines.
Troubleshoot assay and sample analysis issues promptly.
Mentor and guide junior scientists in method development and troubleshooting.
Perform MET ID studies and provide high-quality data interpretation.
Conduct peptide/large molecule bioanalysis using LC-MS/HRMS.
Collaborate with related in vitro verticals for bioanalysis planning.
Review formulation analysis data and resolve issues efficiently.
Ability to mentor and guide junior scientists in troubleshooting and method development.
Lead a team of 3 to 4 scientists, ensuring timely and quality data delivery.
Hands-on experience in LC-MS/MS operation (HRMS experience is advantageous).
Expertise in column selection, mobile phase selection, and sample processing techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction).
Strong understanding of in vitro ADME assays and troubleshooting.
Basic knowledge of large molecule and peptide analysis using LC-MS/HRMS.
Ability to deliver scientific presentations and write official project reports.
Knowledge of quality policies related to data management and integrity.
Strong leadership and mentoring capabilities.
Ability to work professionally and tactfully with teams and external agencies.
Excellent verbal and written communication skills with high transparency.
Team player with strong problem-solving abilities.
Capability to learn and implement new assays in ADME and analytical domains.
Commitment to quality compliance.
All employees are expected to demonstrate the following values consistently:
Excellence
Integrity
Professionalism
Syngene is committed to equal employment opportunities regardless of age, color, national origin, citizenship status, disability, race, religion, gender, sexual orientation, gender identity, genetic information, marital status, veteran status, or any other legally protected characteristic. Reasonable accommodations will be provided for qualified individuals with disabilities.
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