Bbrc - Associate Scientist - Neuroscience

5-7 years

Not Disclosed

Bangalore

10 Jan. 29, 2025

Job Description

Job Type: Full Time Education: B.Sc,M.Sc,B.Pharma,M.Pharma,LifeScience Graduates Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Associate Scientist - Neuroscience (BBRC)
Job Location: Bangalore
Date: 11 Jan 2025
Pay Grade: 8-I
Experience Required: 5-7 years

Company Overview:

Syngene International Ltd., established in 1993, is an innovation-focused, global discovery, development, and manufacturing organization. It provides integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical industries worldwide. Syngene works with leading companies such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA, and Herbalife. The company's 4,240-strong team of scientists helps clients solve scientific challenges, enhance R&D productivity, and reduce the cost of innovation.

Job Purpose:

The Associate Scientist (Neuroscience) will join the Molecular Pharmacology group at BBRC to contribute to the discovery and validation of therapeutic targets for neuropsychiatric diseases. Expertise in neurodegenerative diseases such as Alzheimer’s, Multiple Sclerosis, and neurological conditions like Schizophrenia is highly encouraged.

Key Responsibilities:

Experimental Design and Execution:
- Design and conduct rigorous experiments, including cell-based assays (cell lines, primary neurons, human iPSCs) and biochemical assays, for drug discovery programs focused on neuropsychiatric diseases.
- Perform receptor occupancy assays and analyze target engagement from cell cultures, brain, and peripheral tissues.
- Independently determine in-vitro pharmacologic methods to study modulation of GPCRs and neurotransmitter receptors in primary neurons and human iPSC neurons.
Assay Development and Troubleshooting:
- Develop and troubleshoot assays independently, ensuring accuracy and reliability in the data.
- Record, analyze, and communicate scientific data effectively.
Scientific Literature Review:
- Independently search and review the scientific literature relevant to target biology, keeping up-to-date with advancements in the field.

Educational Qualifications:

MS, MTech, or MPharm in enzymology, biochemistry, molecular biology, or related discipline.

Experience:

5-6 years of experience in neuropharmacology or small molecule pharmacology, with a focus on GPCRs and neurotransmitter receptors at the molecular level in the CNS.

Technical/Functional Skills:

Expertise in neuropharmacology, especially in assessing drug target engagement through biochemical, cellular, and/or radioligand binding assays.
Ability to perform ex-vivo receptor occupancy assays in brain tissues.
Hands-on experience in complex cellular models or ex-vivo systems, designing and executing mechanistic/pharmacological characterization of lead candidates.
Proficient in following pre-established experimental designs and developing new methods, protocols, and technologies based on the existing literature.

Behavioral Skills:

Strong problem-solving and data analysis abilities.
Excellent written and verbal communication skills.
Good presentation skills with the ability to handle multiple projects simultaneously and meet aggressive timelines.
Demonstrates integrity and accountability for their work.

Equal Opportunity Employer:

Syngene is committed to providing equal employment opportunities to all individuals regardless of age, color, national origin, disability, race, religion, gender, sexual orientation, gender identity, or any other characteristic protected by applicable law. The company will also provide reasonable accommodations for qualified individuals with disabilities.

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