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Associate Director, Quantitative Pharmacology And Pharmacometrics Cardiometabolic And Ophthalmic Diseases

6-8 years
$153,800 – $242,200 annually
10 July 4, 2025
Job Description
Job Type: Hybrid Education: B.Sc./M.Sc/B.Pharm/M.Pharm/Life Science Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

 

Associate Director – Quantitative Pharmacology and Pharmacometrics (QP2)

Location: South San Francisco, CA
Company: Merck & Co.
Job Type: Full-Time | Hybrid
Salary Range: $153,800 – $242,200 annually
Application Deadline: July 18, 2025


Job Summary

Merck & Co. is seeking a highly skilled Associate Director, Quantitative Pharmacology and Pharmacometrics (QP2) to join its growing team supporting cardiometabolic and ophthalmology drug development. This hybrid role, based in South San Francisco, offers a unique opportunity to lead end-to-end pharmacometric modeling strategies in one of the world's most research-intensive biopharma companies. The role is ideal for an experienced PK/PD modeling expert with strong cross-functional collaboration and regulatory engagement experience.


Key Responsibilities

  • Lead model-informed strategies for translational PK/PD, POPPK/PD, and clinical trial simulation

  • Represent QP2 on cross-functional discovery and development teams

  • Optimize dose selection, trial design, and go/no-go decisions

  • Collaborate with external vendors and partners to guide regulatory strategies

  • Lead study design, protocol development, and data interpretation

  • Shape and support regulatory submissions through quantitative modeling

  • Mentor junior pharmacometric staff and contribute to team development


Required Skills & Qualifications

  • Ph.D. with 4+ years, PharmD with 6+ years, or MS with 8+ years in quantitative drug development

  • Background in pharmaceutical sciences, pharmacometrics, biopharmaceutics, or biomedical engineering

  • Expertise in population PK/PD modeling using NONMEM, Monolix, Phoenix

  • Strong knowledge in modeling of complex therapeutics and clinical trial simulations

  • Excellent communication, interdisciplinary collaboration, and problem-solving skills

  • Regulatory documentation and submission experience


Preferred Skills

  • Experience in cardiometabolic or ophthalmology clinical drug development

  • Strong knowledge of biopharmaceutical and ADME properties of biologics and small molecules

  • Advanced statistical and modeling capabilities in PKPD, exposure-response analysis


Perks & Benefits

  • Competitive salary: $153,800–$242,200

  • Annual bonus & long-term incentives

  • Full benefits package including medical, dental, vision, and 401(k)

  • Generous vacation, sick leave, holidays, and wellness days

  • Visa sponsorship available

  • Hybrid work flexibility (3 days on-site/week)

  • Opportunity to work in a cutting-edge R&D environment


Company Overview

Merck & Co., a global leader in biopharmaceutical innovation, is committed to transforming healthcare through scientific excellence. Our Quantitative Pharmacology and Pharmacometrics (QP2) team plays a pivotal role in advancing breakthrough therapies for complex diseases like cardiometabolic disorders and eye diseases, using state-of-the-art model-based development approaches.


Work Mode

Hybrid – Minimum 3 days on-site per week in South San Francisco, CA


Call to Action

Ready to lead impactful, model-driven drug development at a global leader in pharma?
Apply now to become part of Merck’s QP2 team and shape the future of clinical pharmacology.