Associate Director – Quantitative Pharmacology and Pharmacometrics (QP2)
Location: South San Francisco, CA
Company: Merck & Co.
Job Type: Full-Time | Hybrid
Salary Range: $153,800 – $242,200 annually
Application Deadline: July 18, 2025
Job Summary
Merck & Co. is seeking a highly skilled Associate Director, Quantitative Pharmacology and Pharmacometrics (QP2) to join its growing team supporting cardiometabolic and ophthalmology drug development. This hybrid role, based in South San Francisco, offers a unique opportunity to lead end-to-end pharmacometric modeling strategies in one of the world's most research-intensive biopharma companies. The role is ideal for an experienced PK/PD modeling expert with strong cross-functional collaboration and regulatory engagement experience.
Key Responsibilities
Lead model-informed strategies for translational PK/PD, POPPK/PD, and clinical trial simulation
Represent QP2 on cross-functional discovery and development teams
Optimize dose selection, trial design, and go/no-go decisions
Collaborate with external vendors and partners to guide regulatory strategies
Lead study design, protocol development, and data interpretation
Shape and support regulatory submissions through quantitative modeling
Mentor junior pharmacometric staff and contribute to team development
Required Skills & Qualifications
Ph.D. with 4+ years, PharmD with 6+ years, or MS with 8+ years in quantitative drug development
Background in pharmaceutical sciences, pharmacometrics, biopharmaceutics, or biomedical engineering
Expertise in population PK/PD modeling using NONMEM, Monolix, Phoenix
Strong knowledge in modeling of complex therapeutics and clinical trial simulations
Excellent communication, interdisciplinary collaboration, and problem-solving skills
Regulatory documentation and submission experience
Preferred Skills
Experience in cardiometabolic or ophthalmology clinical drug development
Strong knowledge of biopharmaceutical and ADME properties of biologics and small molecules
Advanced statistical and modeling capabilities in PKPD, exposure-response analysis
Perks & Benefits
Competitive salary: $153,800–$242,200
Annual bonus & long-term incentives
Full benefits package including medical, dental, vision, and 401(k)
Generous vacation, sick leave, holidays, and wellness days
Visa sponsorship available
Hybrid work flexibility (3 days on-site/week)
Opportunity to work in a cutting-edge R&D environment
Company Overview
Merck & Co., a global leader in biopharmaceutical innovation, is committed to transforming healthcare through scientific excellence. Our Quantitative Pharmacology and Pharmacometrics (QP2) team plays a pivotal role in advancing breakthrough therapies for complex diseases like cardiometabolic disorders and eye diseases, using state-of-the-art model-based development approaches.
Work Mode
Hybrid – Minimum 3 days on-site per week in South San Francisco, CA
Call to Action
Ready to lead impactful, model-driven drug development at a global leader in pharma?
Apply now to become part of Merck’s QP2 team and shape the future of clinical pharmacology.
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