Job Title: Deputy General Manager – Downstream
Req ID: 1327
Date Posted: October 1, 2025
Location: Ahmedabad, India
Company: Lambda Therapeutic Research Ltd.
CTC Range: INR 30,00,000 – 55,00,000
Organizational Overview
Lambda Therapeutic Research is a global full-service Clinical Research Organization (CRO) headquartered in Ahmedabad, India, with operations in Mehsana (India), Las Vegas (USA), Toronto (Canada), Barcelona (Spain), London (UK), and Warsaw (Poland).
Key Highlights:
Offers comprehensive end-to-end clinical research services to global innovator, biotech, and generic pharmaceutical companies
Focused on innovation, quality, and regulatory compliance in clinical research and biopharma development
Job Overview
The Deputy General Manager – Downstream will provide technical leadership for the process development of downstream unit operations in monoclonal antibody (mAb) purification. This role focuses on innovative process development, process characterization, regulatory support, and team leadership.
Key Responsibilities
Lead downstream unit operations: clarification, chromatography, TFF, and formulation for mAb purification
Develop and strengthen capabilities in:
Consistency batches and engineering campaigns
Clinical trial campaigns
Generation of drug substance (DS) for pre-clinical and clinical studies
Virus validation and process improvement
Process characterization using QbD approaches
Process capability studies, cleaning validation, resin/TFF reuse studies
Assess new and cost-effective technologies for mAb and advanced molecule purification (e.g., bispecifics)
Collaborate with CROs for viral clearance studies
Author and review technical reports, unit operations, viral clearance studies, and regulatory submissions to support IND-enabling data
Develop and mentor a highly capable technical staff, providing guidance and professional development
Required Experience
MTech + PhD in Biochemical Engineering or equivalent with 13+ years experience, or
BSc/MSc in Biochemical Engineering or equivalent with 15+ years experience in mAb purification processes from mammalian cell lines in biopharma/biotech or contract research labs
Prior experience leading a team in biopharma organizations focusing on mAb downstream operations is preferred
Skills & Competencies
Expertise in mAb purification, downstream process development, and virus validation
Strong technical leadership and team management skills
Knowledge of QbD, process characterization, and regulatory documentation
Ability to collaborate with CROs and cross-functional teams
Strong mentoring and professional development abilities
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