Job Title
Senior Advisor, Biotransformation
Location
Indianapolis, Indiana, United States
Company
Eli Lilly and Company
Category
Research & Development
Job Type
Full Time | Regular
Job ID
R-84188
Position Summary
The Biotransformation group within Lilly’s DMPK (Drug Metabolism and Pharmacokinetics) organization is seeking a Senior Advisor to lead and implement biotransformation studies in drug discovery and development. The role involves overseeing and conducting in vivo and in vitro metabolism studies, analyzing biotransformation results, solving mechanistic questions, and collaborating across DMPK fields.
Key Responsibilities
Independently design, conduct, troubleshoot, and oversee cold and radiolabeled in vitro/in vivo biotransformation studies for small molecules and new modalities (e.g., peptides).
Use mass spectrometry for biotransformation assessments to inform drug design.
Design and guide critical experiments involving sample extraction, LC/MS, and radiometric profiling.
Evaluate, implement, and innovate new technologies and strategies for biotransformation capabilities.
Integrate data across functions to interpret drug metabolism and clearance mechanisms.
Mentor and supervise junior scientific staff.
Apply regulatory guidelines for biotransformation (e.g., MIST, metabolite DDI, reactive metabolites).
Collaborate internally and externally (e.g., with CROs).
Author and review scientific reports, publications, and manuscripts.
Represent Lilly in external scientific communities.
Communicate results effectively across DMPK teams and with project management.
Education Requirements
PhD in Organic Chemistry, Medicinal Chemistry, Natural Products Chemistry, or Analytical Chemistry.
Minimum 7+ years of biotransformation experience.
Additional Qualifications/Attributes
Experience with Accelerator Mass Spectrometry (AMS) studies (ABA, mass balance, radioprofiling).
Strong understanding of clearance mechanisms and enzymes involved in drug biotransformation.
Compensation
Salary Range: $142,500 - $228,800 (depending on education, experience, skills, and location)
Additional Compensation: Eligible for company bonus based on company and individual performance
Benefits Include:
401(k) plan
Pension plan
Paid vacation
Medical, dental, vision, and prescription drug benefits
Flexible spending accounts
Life insurance and death benefits
Well-being benefits (e.g., EAP, fitness benefits)
Equal Opportunity Employer
Lilly provides equal employment opportunities without discrimination based on any legally protected characteristic.
Employee Resource Groups (ERGs)
Lilly offers ERGs including Black Employees at Lilly, Chinese Culture Network, PRIDE (LGBTQ+ Allies), Women’s Initiative for Leading at Lilly (WILL), and others.
Accommodation
Applicants needing accommodation during the application process can submit a request via the Accommodation Request Form.
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