🧪 Job Title: Scientist (Oligo Synthesis) – SBX Molecular Engineering
Company: Roche
Location: Seattle, Washington, United States
Department: Research & Development
Job ID: 202510-126565
Category: Molecular Engineering / Research & Development
Employment Type: Full-time
Relocation Benefits: Available
Salary Range: USD 81,100 – 150,700 (based on experience and location)
Bonus: Discretionary annual bonus (performance-based)
🌍 About Roche
Roche is a global healthcare innovator with over 100,000 employees worldwide, advancing science to ensure healthcare access today and for future generations.
26 million+ people treated with Roche medicines annually
30 billion+ diagnostic tests conducted using Roche products
Roche encourages authenticity, inclusion, and open dialogue — ensuring every voice is valued and respected.
🔬 About the Team – SBX Molecular Engineering
In 2020, Roche Diagnostics acquired Stratos Genomics for its revolutionary Sequencing by Expansion (SBX™) chemistry — a breakthrough nanopore sequencing technology.
The Molecular Engineering team designs and synthesizes molecular building blocks that translate DNA sequences into “Xpandomers,” improving accuracy and throughput of nanopore sequencing.
This team is passionate about pioneering molecular innovation to enhance patient outcomes and the future of genetic analysis.
🎯 Position Objective
The Scientist (Oligo Synthesis) will:
Research, design, and execute experiments to engineer and synthesize oligonucleotide-based molecular components.
Support the production and optimization of reagents and starting materials.
Contribute to advancing SBX nanopore sequencing technology through innovative molecular engineering.
💡 Note: Applicants must include a cover letter describing their interest in SBX technology, technical expertise, and how they can contribute to the team.
⚙️ Key Responsibilities
1. Experimental Design & Execution
Design and perform innovative, well-controlled experiments with precision and accuracy.
Identify, troubleshoot, and creatively resolve technical challenges.
Conduct synthesis using advanced oligo chemistry principles.
Analyze and interpret experimental data, proposing protocol refinements.
2. Production & Process Development
Follow Standard Operating Procedures (SOPs) to aid reagent production.
Participate in large-scale reagent and starting material synthesis.
Maintain detailed laboratory records and ensure data integrity.
Develop and propose process improvements for synthesis and lab workflows.
3. Collaboration & Communication
Present findings at team or departmental meetings.
Maintain lab organization, safety, and cleanliness.
Work collaboratively with molecular engineers and chemists to meet project milestones.
🧬 Qualifications & Experience
Required:
Bachelor’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry, or related field.
Minimum 2 years of laboratory experience in advanced oligonucleotide synthesis (e.g., non-standard phosphoramidites, branched/cyclic structures, or modified reagents).
Preferred:
MS or PhD degree in a relevant discipline (5+ years of experience for BSc; fewer years acceptable with higher degree).
Expertise in developing novel oligo synthesis chemistry including:
Phosphoramidite coupling
Oxidation
Detritylation
Capping
Experience with automated oligo synthesizers and complex fluidic systems.
Solid understanding of chemical and biochemical sample handling, including purification and storage.
Technical background in next-generation DNA sequencing.
Proficiency with HPLC, Mass Spectrometry (MS), NMR, and inert atmosphere handling.
💡 Core Competencies
Strong analytical and troubleshooting skills.
Excellent documentation and data analysis capabilities.
Attention to detail and lab precision.
Effective teamwork and communication within cross-functional environments.
Creative problem-solving and adaptability in fast-paced research settings.
💰 Compensation & Benefits
Annual Salary: USD 81,100 – 150,700 (based on qualifications and geography)
Bonus: Discretionary annual bonus based on performance
Benefits: Comprehensive health, wellness, and retirement benefits (see Roche Benefits page)
Relocation Support: Available for eligible candidates
⚖️ Equal Opportunity Statement
Roche is an Equal Opportunity Employer, committed to fairness, diversity, and inclusion.
All employment decisions are based on merit and qualifications, without discrimination on any protected basis (e.g., veteran status, disability, race, gender, or local law protections).
📩 Applicants needing accommodations during the application process can contact Roche through the Accommodations for Applicants form.
🌱 Mission Statement
“A healthier future drives us to innovate — giving everyone more time with the people they love.”
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