Research Scientist, Biochemistry

2+ years

Not Disclosed

Cambridge

10 July 31, 2024

Job Description

Job Type: Full Time Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Summary

Location: Cambridge, MA #LI-Onsite

The Novartis Oncology Disease Area is seeking a highly motivated, creative, and collaborative scientist to join the Biological Chemistry (BC) group. This role offers a hands-on opportunity to discover innovative cancer treatments. As an early-stage drug discovery team, we focus on understanding and leveraging the molecular mechanisms of novel cancer targets for developing, characterizing, and optimizing small molecule therapeutics.

About the Role

Key Responsibilities:

Assay Development: Design, develop, and troubleshoot biochemical and biophysical assays using various detection technologies to identify and characterize cancer targets and small molecule modulators.
Binding Analysis: Measure binding affinity, kinetics, and understand the mode of binding of ligands to proteins of interest.
Technology Integration: Assess and implement emerging technologies and novel assay approaches to advance drug discovery programs.
Medicinal Chemistry: Contribute to medicinal chemistry efforts, including evaluating compound SAR (structure-activity relationship) and mode of action characterization.
Collaboration: Communicate, collaborate, and challenge assumptions to push scientific boundaries with a diverse team of cross-functional scientists.

Note: This position is based at the Novartis Cambridge (MA) site and does not offer remote work options. It also does not require travel.

Compensation

The expected pay range for this position is $66,000 to $99,000 per year. This range is effective from 1/1/24 to 12/31/24, with potential adjustments based on job market fluctuations. Final pay will depend on various factors including location, experience, skills, and other considerations. The total compensation package may include additional elements such as a sign-on bonus, restricted stock units, discretionary awards, and a comprehensive benefits package.

Essential Requirements

Educational Background: Minimum of a bachelor’s degree in Biochemistry, Biophysics, Enzymology, or a related field with 1+ years of relevant laboratory research experience through employment, internships, or co-op programs. Or a master’s degree with 0-1 years of relevant experience.
Technical Expertise: Solid understanding of protein function and enzyme mechanisms. Experience in biochemical and/or biophysical assay development for protein target and small molecule inhibitor characterization, as well as protein-ligand binding interactions.
Bench Skills: Strong technical ability at the bench, eagerness to learn, and willingness to tackle challenging scientific questions.
Team Collaboration: Experience working with multidisciplinary project teams.
Assay Techniques: Experience with fluorescence-based assay techniques (e.g., HTRF, FP, or quench assays) and label-free technologies (e.g., SPR, ITC, DSF, or mass spectrometry).
Data Analysis: Proven ability to analyze, interpret, and present data clearly and concisely.
Communication: Excellent team player with strong communication and interpersonal skills.

Desirable Requirements

Automation Experience: Hands-on experience with automation for medium to high throughput assays.

Benefits and Rewards

Explore our benefits handbook to learn how we support your personal and professional growth.

Commitment to Diversity and Inclusion

Novartis is dedicated to creating an inclusive work environment and diverse teams representative of the patients and communities we serve.

Why Novartis?

At Novartis, innovative science and a collaborative, supportive community drive us to achieve breakthroughs that change patients' lives. Discover more about our mission and culture here.

Join our Network: Not the right role for you? Stay connected by joining our talent community to learn about future opportunities. Sign up here.

EEO Statement: Novartis is an Equal Opportunity Employer committed to maintaining a diverse environment. We do not discriminate based on race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations: If you need reasonable accommodations for any part of the application process or to perform essential job functions due to a disability, please contact us at us.reasonableaccommodations@novartis.com or call +1(877)395-2339, including the job requisition number in your message.

Division: Biomedical Research
Business Unit: Pharma Research
Location: USA
Site: Cambridge (USA)
Company / Legal Entity: Novartis Institutes for BioMedical Research, Inc.
Functional Area: Research & Development
Job Type: Full time
Employment Type: Regular
Shift Work: No

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