Principal Scientist, Single Cell & Spatial Proteomics

3 years

$115,000 – $197,800 USD

Massachusetts

10 Sept. 10, 2025

Job Description

Job Type: Full Time Education: PhD in Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology, or related field Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title

Principal Scientist, Single Cell & Spatial Proteomics

Company

Johnson & Johnson – Innovative Medicine

Location

Cambridge, Massachusetts, United States of America
Work Pattern: Fully Onsite

Function & Category

Function: Discovery & Pre-Clinical/Clinical Development
Sub-Function: Biological Research
Job Category: Principal Scientist, Biological Research (ST7)

Requisition Number

R-028467

Date Posted

August 28, 2025
Application Deadline: October 31, 2025 (may be extended)

About the Role

As part of the Discovery Proteomic Platforms (DPP) group within the Multiomics Discovery Team, the Principal Scientist will contribute to cutting-edge research by building and applying advanced proteomic platforms to support drug discovery efforts in Oncology, Immunology, and Neuroscience.

The ideal candidate will bring expertise in single-cell and spatial proteomics, mass spectrometry, and liquid chromatography to support target identification, validation, and therapeutic optimization in a collaborative, interdisciplinary setting.

Key Responsibilities

Lead development and deployment of novel single cell and spatial proteomics platforms.
Work with cross-functional teams, including bioinformatics and biostatistics experts, to derive actionable insights.
Design and perform wet-lab experiments for:
- Target engagement and identification
- Therapeutic optimization
- Interactome analysis
Operate and maintain next-generation LC-MS systems, ensuring high-throughput and high-quality data generation.
Present findings at internal meetings and contribute to project discussions.
Demonstrate scientific creativity and propose innovative solutions aligned with strategic goals.

Required Qualifications

Education:
- PhD in Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology, or related field
Experience:
- Minimum 3 years of hands-on experience in an industrial mass spectrometry lab
- Proven expertise in liquid chromatography (Vanquish Neo or Evosep One) and mass spectrometry (Bruker timsTOF, Thermo Tribrid)
- Strong experience in processing and analyzing large-scale proteomics datasets
- Skilled in single-cell or spatial proteomics
- Ability to manage multiple concurrent projects in a fast-paced environment
- Strong interpersonal and collaboration skills

Preferred Qualifications

Industry experience in a pharmaceutical or biotech setting
Familiarity with Thermo Astral and Evosep instruments
Experience with lab automation platforms such as:
- AssayMAP Bravo
- Beckman Biomek
- Hamilton Microlab STAR
- TECAN Fluent
- Dynamic Devices Lynx
Experience in microscopy for spatial proteomics or handling systems like Cellenone and Uno

Compensation

Anticipated Base Pay Range:
$115,000 – $197,800 USD

Additional Compensation:

Eligible for annual performance bonus
Eligible for long-term incentive program

Benefits Overview

Eligible employees and dependents may participate in the following benefits programs:

Medical, dental, and vision insurance
Life insurance and business accident insurance
Short- and long-term disability
Group legal insurance
Retirement Plans: Pension and 401(k) savings
Paid Time Off:
- Vacation: up to 120 hours/year
- Sick Time: up to 40 hours/year (56 hours for WA residents)
- Holidays: up to 13 days/year
- Work, Personal & Family Time: up to 40 hours/year

More details: Johnson & Johnson Benefits

Equal Opportunity Employer

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will be considered regardless of race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status, or other legally protected characteristics. We encourage applications from protected veterans and individuals with disabilities.

Accommodation Statement

If you need an accommodation due to a disability, please contact:
📧 Careers Support
Or use AskGS to be directed to your accommodation resource.

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Principal Scientist, Single Cell & Spatial Proteomics

Job Description

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