🧬 Job Title: Principal Research Scientist – Sequencing Applications
Company: Roche
Location: Pleasanton, California, United States
Department: Research & Early Development – Sequencing Workflows and Applications Team
Job ID: 202509-122225
Category: Research & Development
Employment Type: Full-time (On-site)
Relocation Benefits: Not available
Salary Range: USD 108,400 – 201,200 (based on experience and qualifications)
Bonus: Discretionary annual bonus (performance-based)
🌍 About Roche
At Roche, innovation is driven by passion for transforming patients’ lives. With 100,000+ employees globally, Roche is dedicated to advancing science, ensuring access to medical innovations, and building a better world through ethical, evidence-based work.
“Good business means a better world — that’s why we come to work every day.”
Roche fosters a culture of authenticity, open communication, and inclusion — empowering every employee to thrive personally and professionally.
🔬 About the Team – Sequencing Workflows & Applications
The Sequencing Workflows and Applications Team is part of Roche’s Research and Early Development division.
Its mission is to develop cutting-edge sequencing applications for Roche’s revolutionary Axelios Sequencing Platform, powered by Sequencing by Expansion (SBX™) technology.
This team bridges molecular innovation with practical, real-world healthcare solutions that enhance patient outcomes.
🎯 Position Objective
The Principal Research Scientist will lead the design and development of novel sequencing workflows and applications that bring SBX™ technology to life.
You will translate scientific potential into clinical impact through:
Hands-on experimentation
Innovation in workflow design
Collaboration with cross-functional teams and external partners
This is a lab-based role for a visionary scientist ready to lead high-impact R&D projects and shape the future of next-generation sequencing (NGS).
⚙️ Key Responsibilities
1. Scientific Innovation & Leadership
Design, execute, and optimize novel sequencing workflows using SBX™ and other NGS technologies.
Lead complex hands-on laboratory experiments with high scientific rigor.
Troubleshoot, interpret, and resolve assay and workflow challenges.
Invent and prototype advanced sequencing applications.
2. Collaboration & Mentorship
Mentor junior scientists and promote a culture of creativity and scientific excellence.
Collaborate with:
Commercial and clinical partners
External researchers
Internal bioinformatics and engineering teams
Present scientific findings to internal stakeholders and at external conferences.
3. Data Interpretation & Application Development
Analyze complex datasets using standard bioinformatics pipelines and sequencing metrics.
Translate technical findings into application notes, publications, and customer-facing materials.
Support new product launches through application development and technical documentation.
4. Strategic Contribution
Identify and champion emerging technologies that align with Roche’s R&D goals.
Contribute to long-term strategic planning and innovation roadmap development.
🧠 Required Qualifications
Degree in Molecular Biology, Genetics, Biochemistry, or related field.
PhD with 3+ years of relevant industry experience, OR
Master’s with 6+ years of experience, OR
Bachelor’s with 8+ years of experience.
Deep understanding of molecular biology for NGS sample preparation.
Proven experience in designing and optimizing multiple distinct NGS workflows.
Hands-on experience with advanced sequencing methods such as:
Single-cell sequencing
Protein detection by sequencing
Spatial sequencing
Proficiency in interpreting bioinformatics outputs and genomic analysis metrics.
Excellent communication, organizational, and multitasking skills.
Strong ability to manage multiple complex projects and shifting priorities.
🌟 Preferred Qualifications
Experience with multiple NGS platforms (e.g., Illumina, PacBio, Oxford Nanopore).
Familiarity with automation systems (e.g., Hamilton, Tecan).
Record of scientific innovation, evidenced by patents or peer-reviewed publications.
Experience with Design of Experiments (DOE) and Statistical Process Control (SPC).
Strong technical writing and presentation skills.
💰 Compensation & Benefits
Salary Range: USD 108,400 – 201,200 (based on experience and geography).
Bonus: Discretionary annual performance-based bonus.
Benefits: Comprehensive health, wellness, and retirement benefits.
Roche Benefits Overview (link placeholder)
⚖️ Equal Opportunity Statement
Roche is an Equal Opportunity Employer that values diversity and inclusion.
All employment decisions are made based on merit, qualifications, and competence, without discrimination based on race, gender, veteran status, disability, or other protected categories.
If you need an accommodation during the application process, you can contact Roche through the Accommodations for Applicants form.
🌱 Mission Statement
“We advance science so everyone can have more time with the people they love.”
Together, Roche employees deliver life-changing healthcare innovations that make a global impact.
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