Principal II Scientist – Applied Chemistry, Fluidic Systems, Research & Early Development
Location: Santa Clara, California, United States
Category: Research & Development
Job ID: 202510-125749
Company Overview:
Roche is a global leader in healthcare innovation, advancing next-generation sequencing (NGS) solutions to accelerate clinical research and improve patient outcomes. Our integrated platforms span sample preparation, sequencing, and bioinformatics, creating seamless “sample in, result out” workflows. Roche fosters a culture of inclusion, scientific excellence, and continuous learning, empowering employees to innovate and thrive professionally.
Position Overview:
Roche Sequencing Solutions is seeking a Principal II Scientist to lead applied chemistry initiatives within our Systems Technology Group. This hands-on role requires a multidisciplinary expert capable of developing and integrating novel chemical processes and formulations to enhance the performance, reliability, and longevity of complex fluidic systems. You will lead early-stage R&D projects, collaborate with engineers across materials, mechanical, and consumables disciplines, and translate fundamental chemistry into practical system solutions.
Key Responsibilities:
Chemistry Innovation & Process Development:
Invent, screen, and validate chemical formulations and buffer additives to reduce biofouling and non-specific adsorption.
Develop novel chemistries and conjugation methods for coating, polymer, and biomolecule attachment to diverse surfaces.
Optimize chemical processes to ensure robust, reproducible performance and eliminate carryover in fluidic systems.
Conduct root cause investigations for system-level contamination and process inefficiencies.
Assay Development & System Performance:
Design and implement analytical workflows to assess surface modifications, ligand density, binding capacity, and chemical stability.
Develop trace contaminant detection methods using advanced instrumentation and external laboratory collaborations.
Utilize modeling and simulation tools to optimize chemical and fluidic workflows and predict system behavior.
Workflow Implementation & System Troubleshooting:
Conduct hands-on experiments with breadboards, custom fixtures, and prototype systems to optimize chemical workflows.
Troubleshoot complex, integrated systems using first-principles problem-solving spanning chemistry, materials, hardware, and software.
Cross-Functional Collaboration & Strategy:
Serve as the subject matter expert on applied chemistry, collaborating with engineers to select, test, and qualify materials for chemical compatibility.
Integrate chemical processes with system architecture, ensuring proper fluidic control, thermal management, and automated protocols.
Manage external analytical partnerships, ensuring high-quality data, cost-effectiveness, and efficient workflows.
Analyze complex data, author technical reports, generate IP, and present strategic recommendations to leadership.
Experience & Qualifications (Required):
PhD in Chemistry or related field with 7+ years of industry experience, OR Master’s degree with 9+ years, OR Bachelor’s degree with 11+ years of relevant industry experience.
Hands-on expertise in surface chemistry, bioconjugation, and solid-liquid interface interactions.
Proven experience developing chemical processes for complex fluidic or microfluidic systems in life sciences, sequencing, or diagnostics.
Extensive experience developing and implementing analytical assays to quantify chemical performance.
Proficiency in chemical and materials characterization techniques.
Strong problem-solving skills in complex, integrated systems.
Demonstrated ability to lead technical initiatives and mentor junior scientists.
Excellent organizational, communication, and interpersonal skills for cross-functional collaboration.
Preferred Qualifications:
Experience with NGS chemistry, solid-phase oligonucleotide synthesis, and multi-step enzymatic workflows.
Expertise in surface characterization, contamination mitigation, DOE, and SPC methodologies.
Proven track record of innovation with patents and/or publications.
Experience managing external labs and service agreements.
Action-oriented, decisive problem-solver with a passion for scientific discovery.
Location & Compensation:
On-site: Santa Clara, California (not hybrid).
Salary Range: $125,500 – $233,500, based on experience, qualifications, and location.
Discretionary annual bonus may apply.
Comprehensive benefits package included.
Why Join Roche:
Roche offers a unique opportunity to lead applied chemistry innovation in next-generation sequencing, driving breakthroughs that impact global healthcare. Collaborate with top-tier scientists and engineers in a fast-paced, cutting-edge R&D environment. Roche is committed to inclusion, professional growth, and empowering employees to deliver life-changing healthcare solutions.
Application & Accommodation:
Candidates requiring accommodations during the application process may contact Roche via the Accommodations for Applicants form.
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