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Head Quality Review, Clinical Development

15+ years
Not Disclosed
10 Jan. 29, 2025
Job Description
Job Type: Full Time Education: B.Sc,M.Sc,B.Pharma,M.Pharma,LifeScience Graduates Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Head Quality Control Review, Clinical Development

Date: 18 Jan 2025
Job Location: Semicon Park, Bengaluru
Reporting to: Operating Unit Head, Clinical Development
Pay Grade: 
Years of Experience: 15+ years

Company Overview

Syngene International Ltd. is an integrated research, development, and manufacturing solutions company. It serves the pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical sectors globally. With over 4500 scientists and a strong innovation-driven approach, Syngene collaborates with leading companies such as Amgen, Baxter, Bristol-Myers Squibb, GSK, and Merck KGaA. The company operates extensive discovery, development, and manufacturing facilities.

Safety and Compliance Expectation

  • Adhere to Syngene's safety guidelines and procedures, ensuring a safety-first environment.
  • Contribute to the development of procedures that ensure compliance with environmental, health, and safety standards.
  • Promote safety as a core value across all teams and adhere to data integrity and safety measures.

Role Summary

The Head of Quality Control Review plays a pivotal role in ensuring that the Clinical Development Operating Unit (OU) meets and exceeds quality standards. The role involves supporting the operating teams to enhance quality control, SOP refinements, and maintaining "anytime audit readiness."

Key Responsibilities

Support Operating Teams & QA:

  1. Track Quality Metrics:
    Support operating teams to track and sustain quality metrics that ensure performance and compliance across all departments, meeting both regulatory and internal standards.

  2. Enhance SOPs & Processes:
    Lead initiatives to refine SOPs and workflows in collaboration with operating teams, enhancing operational efficiency and regulatory compliance.

  3. Audit Support:
    Assist in regulatory audits, internal audits, and inspections by ensuring compliance with laws and standards.

  4. Error Minimization & Process Improvement:
    Collaborate with section heads and the QA team to reduce errors, fostering a culture of continuous improvement and compliance.

  5. Quality Control Issues Management:
    Address quality control issues by collaborating with operational teams and implementing corrective action plans.

  6. Audit Readiness:
    Maintain a state of “anytime audit readiness” by conducting regular internal reviews and implementing robust quality control systems.

  7. Continuous Improvement:
    Support operating teams in process simplification and driving quality improvement initiatives to sustain world-class quality KPIs.

BA/BE Section (Bioavailability/Bioequivalence):

  1. Quality Control Plan Execution:
    Oversee and implement the QC Review Plan for each study, ensuring that it aligns with required standards.

  2. Monitoring & Oversight:
    Monitor protocol compliance, documentation, and conduct clinical study reviews to maintain data integrity.

  3. Quality Control Processes:
    Define processes for managing and approving source documents, verifying inclusion/exclusion criteria, and ensuring data consistency.

  4. Documentation & Compliance:
    Ensure that all QC observations are addressed in a timely manner before data entry and that the QC Review process is thoroughly documented.

  5. Client & Team Interaction:
    Meet regularly with clients to discuss protocol adherence, resolve deviations, and report on QC observations.

  6. Regulatory Documentation:
    Ensure the regulatory/TMF binder is ready for archiving by overseeing the QC review process at the conclusion of the study.

Bioanalytical Laboratory Operations:

  1. Data Integrity & Review:
    Conduct checks on data integrity across method development, validation, and sample analysis.

  2. Collaborative Problem Solving:
    Work with study directors to identify errors, propose solutions, and establish corrective actions.

  3. Audit Support:
    Assist in audits to ensure compliance with regulatory and internal standards.

  4. Quality Control of Laboratory Practices:
    Review laboratory logbooks, calibration records, and ensure the facility’s compliance with regulatory standards.

  5. Data Trend Analysis:
    Support quality transformation initiatives by analyzing monthly QC observations.

Central Laboratory Section Activities:

  1. Quality Control Checks:
    Oversee pre-analytical, analytical, and post-analytical activities to ensure they meet QC standards.

  2. Data Verification:
    Ensure manually transcribed data is accurate and aligns with worksheets, guaranteeing data integrity.

  3. Logbook Management:
    Maintain controlled logbooks, ensuring records are legible and compliant with lab standards.

  4. Instrument Maintenance & Calibration:
    Ensure all lab equipment is regularly maintained and calibrated to meet industry standards.

Clinical Trials, Data Management, and Pharmacy Section Activities:

  1. System Reviews:
    Conduct internal reviews of the Clinical Trial Management department and Clinical Supply Unit to ensure compliance with GCP, SOPs, and regulatory requirements.

  2. SOP and Training Review Coordination:
    Oversee SOP reviews and ensure training binders reflect current practices and standards.

  3. Quality Issue Reporting:
    Report quality issues promptly and ensure reporting aligns with established operating procedures.

  4. Syngene Clinical Supply Unit QC Checks:
    Perform quality checks on the Clinical Supply Unit as part of oversight for system integrity.

Leadership Responsibilities:

  1. EHSS Leadership:
    Champion effective Environment, Occupational Health, Safety, and Sustainability (EHSS) practices and compliance.

  2. People Leadership:
    Lead with the Syngene leadership framework, focusing on talent retention, career planning, and people management.

  3. Foster Corporate Culture:
    Drive a culture of quality, collaboration, and integrity across the organization.

Education and Experience

Educational Qualifications:

  • M. Pharm or MSc in life sciences (minimum requirement).
  • PhD (advantageous).

Industry Experience:

  • At least 15 years in a GxP and compliance environment, with a strong understanding of processes and compliance in GxP.
  • Experience in GCP and GLP is critical.

People Leadership:

  • Minimum 7 years of experience leading teams directly and working cross-functionally in a metrics-driven environment.

Other Competencies:

  • People Skills: Proven experience in leading change and fostering a culture of collaboration.
  • Scientific Innovation: Strong interest in scientific innovation in a commercial setting.
  • Customer Focus: Proven track record in delivering business growth and results.
  • Strong Industry Knowledge: Well-networked with industry expertise.
  • Impeccable Ethics: Strong ethical standards and ability to work in a multi-cultural environment.

Equal Opportunity Employer

Syngene is committed to providing equal employment opportunities (EEO) to all individuals, regardless of age, color, national origin, disability, race, religion, gender, or any other characteristic protected by applicable legislation. Reasonable accommodations will be provided for qualified individuals with disabilities.